i feel like bands like mayday parade an ymas and we the kings all sound the exact same and it just...


i feel like bands like mayday parade an ymas and we the kings all sound the exact same and it just gets reaaal boring and idgi because those bands get the most attention lately

they don?t suck they just all clash imo

same deal with bands like devil wears prada, august burns red, as i lay dying etc

so i feel like bands like fir, the used, senses fail etc are such a breath of fresh air because they sound unique but not in an obnoxious way

/random

Source: http://when-both-our-cars-collide.tumblr.com/post/28817132524

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Source: http://www.monochrome-photo.com/?p=244

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ZTE Grand X reaches UK shops a tad early through Phones4U

ZTE Grand X reaches UK shops a tad early through Phones4U

Virgin Mobile had originally promised the UK version of the ZTE Grand X for early August. The carrier just can't contain its enthusiasm: it's letting retail partner Phones4U sell the budget smartphone as of today. While you're busy skipping the start of the Olympics, the store will give you a Grand X for free if you're willing to spend at least £20.50 ($32) per month on a tariff instead of opting for the £190 ($299) pay-as-you-go hardware price. As we saw in China, the appeal of the Grand X is in those numbers -- it's more the temptation of stock Android 4.0 in a low-priced (if capable) suit than the hardware. Phones4U does hope to sweeten the pot through a contest. We hope you like the musical styles of Professor Green, as the British retailer is giving early Grand X adopters a chance to win both a custom Professor Green case as well as tickets to a private concert.

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ZTE Grand X reaches UK shops a tad early through Phones4U originally appeared on Engadget on Fri, 27 Jul 2012 17:04:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/07/27/zte-grand-x-reaches-uk-shops-a-tad-early-through-phones4u/

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Toronto Team Building Activities to generate Your Business Team ...

It is very easy for an office building staff to become satisfied. They can fall into any routine where these people become very unbiased and rely on their own fellow workers less. While this may seem like a very important thing, many office responsibilities can be accomplished quicker far better when the team really does them as a whole instead of relying on the enter of only one person. In case a business is in Toronto, team building events activities from a firm like XPEERience Group can help create that ?we? frame of mind again.

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Something that a lot of companies will do is have a staff meeting to discuss the outing the next time your entire staff is together on the job. Keep it very casual and talk about the different events and how the particular winning teams were able to perform so well. Maintain stressing how they employed each person?s strengths to aid the team perform far better.

Once this topic gets rolling, start to bring up examples of tasks around the office that have been delayed because the ?team? had not been working together. Keep in mind this is not a disciplinary meeting, simply a reinforcement of how efficient it is to work together. From that point, hand out exactly the same assignment to both of these individuals and teams. Allow them to have a limited time to develop them and then keep a meeting later within the day to monitor progress.

While there may be a lot of people capable of pulling off the upset victory, generally, the teams will be able to present a better plus much more complete project. This is where management can enhance the idea of how important it is to work together whenever possible instead of working alone all the time. It won?t be long before the entire workplace benefits from the Toronto team building activities they appreciated during the outing.

For more information about Keynote Speaker Toronto visit our website.

This entry was posted in blog and tagged Keynote Speaker Toronto. Bookmark the permalink. Both comments and trackbacks are currently closed.

Source: http://artyapt.com/blog/toronto-team-building-activities-to-generate-your-business-team-more-efficient/

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Treasure Coast Real Estate | North Passage 02 Homes For Sale ...

by starfish on July 27, 2012

Find North Passage 02 Homes For Sale and North Passage 02 Home Values. We also have information on mortgages, insurance, movers and other Treasure Coast Real Estate Services for anyone looking to sell or buy a home in beautiful Martin COUNTY Florida.

Paul Kitchen and Starfish Team provide clients, family and close friends with professional, honest and dependable service. A resident of Treasure Coast, Paul is extremely familiar with the local neighborhoods including North Passage 02, school districts and the Treasure Coast Real Estate market in this beautiful Florida town

Paul Kitchen
Broker-Owner
Starfish Real Estate
8985 SE Bridge Road Hobe Sound, Florida 33455
(561) 935-9412
(800) 793-7304 toll free
Treasure Coast Real Estate
Treasure Coast Real Estate Blog

Starfish Real Estate

Source: http://www.treasure-coast-living.com/2012/07/27/treasure-coast-real-estate-north-passage-02-homes-for-sale-july-2012-2/

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Make A Social Media Advertising Difference By Way Of These Tips ...

You are here: Home / General / Make A Social Media Advertising Difference By Way Of These Tips

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Source: http://www.theyellowads.com/computers_technology/make-a-social-media-advertising-difference-by-way-of-these-tips/

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DeMarco: A tall task for Phillies' Amaro

GM must retool team while staying in win-now mode

Image: Cole Hamels, Ruben AramoAP

Phillies general manager Ruben Amaro signed ace Cole Hamels to a new contract this week, but has much more work to do to retool his team.

OPINION

By Tony DeMarco

NBCSports.com contributor

updated 6:31 p.m. ET July 26, 2012

Tony DeMarco

Thanks in part to the gift-giving tendencies of the Milwaukee Brewers' bullpen, the Philadelphia Phillies have run off a four-game winning streak ? three by walk-offs ? and generated some excitement in a season of miserable underachieving.

But they shouldn't be deceived about making a run for the playoffs ? an unlikely long shot after 99 games, nine games under .500, 9 1/2 games behind the second wild card and six teams to pass ? not to mention with two of three aces not pitching that way.

Instead, it's time for the front office to focus on what the roster will look like in 2013 and the near-beyond, when the Phillies will take another shot at winning a World Series before their aging core players reach the end of the line.

At the precipice of the luxury-tax threshold ? and with a 254-game-and-counting consecutive sellout streak at Citizens Bank Park ? the Phillies' only option is to reload.

"We're trying to be improvers,'' is how club president David Montgomery put it on Wednesday.

Montgomery was speaking at the press conference for Cole Hamels' six-year, $144-million contract extension, which was the first ? and very correct ? step in this process. Of all their pricey pieces, Hamels was the one they least could afford to lose ? a 28-year-old ace in the midst of his best season, smack in the prime of his career, seemingly with a half-dozen or so elite-level seasons in front of him.

This really was a compromise for both sides. Not that long ago, the Phillies had shown reluctance to go beyond three guaranteed years for pitchers (see Halladay, Roy). But the game's financial landscape has changed, and for as much as Hamels received ? reportedly a $6-million signing bonus, $19.5 million in 2013, $22.5 million per year in 2014-18 and either a vesting option for 2019 or $6-million buyout ? there is a feeling he could have received more in free agency.

In fact, when you consider that the Angels, Dodgers, Yankees and Red Sox all are in need of another front-of-the-rotation starter, CC Sabathia's record seven-year, $161-million deal seemed to be in jeopardy. So Hamels most likely took a bit less to stay with the only organization he has known since being picked 17th overall in the 2002 draft.

The legitimate question to ask is did the Hamels deal inhibit putting enough pieces in place to win in the near future? Look at the top-heavy financial obligations general manager Ruben Amaro Jr. faces in trying to add pieces to a puzzle that has come up way short this season. In 2013, the Phillies will pay (numbers from the Baseball Prospectus/Cots Baseball Contracts site):

  • $70.5 million to three starting pitchers ? Lee ($25 million), Halladay ($20), Hamels ($25.5 including signing bonus)
  • $90.5 million to four players, adding Ryan Howard ($20 million).
  • $129.5 million to seven players, adding Chase Utley ($15 million), Jonathan Papelbon ($13 million) and Jimmy Rollins ($11 million). And that's not counting Hunter Pence's arbitration-eligible salary, which should land between $13-$15 million.

Keep in mind that the Phillies' payroll was a tad under $100 million when they won the 2008 World Series. But the reality is the Phillies had no choice but to extend Hamels; he's that important going forward. Still, their needs are clear: third base, bullpen, outfield.

Dealing Lee would go the furthest to alleviate financial concerns, as he's owed $87.5 million (buyout included) over the next three seasons. But, that obligation limits his market to the financial elites ? Rangers (who have reported interest), Yankees, Dodgers, Angels, Red Sox and maybe a sleeper team or two.

It also doesn't help that Lee clearly is in a down year, and is nowhere near the league-elite starters. Forget the no-run-support argument; his ERA is 3.95 ? up 1.55 from his 2011 season mark, and by far his worst since 2007, when the Indians sent him back to the minors. Other measures similarly have risen, including WHIP, hits-per-nine innings and home-run ratio.

Still, you'd think he could bring a return that would fill two of those roster holes. But the Phillies have invested so much in their pitching since their postseason run began in 2007, it would mark a dramatic change in course for them to trade from their ultimate strength (actual or perceived). So count a potential Lee deal as the highest in both risk and reward; a truly gutsy move by Amaro, if he goes that way.

The Pence trade speculation seems strange, given that the Phillies let Jayson Werth and Raul Ibanez go over the last two winters, and it's highly likely Shane Victorino is in his final couple of months (or even week) in a Phillies uniform. How many outfielders can you let get away, especially when nobody has stepped up from the system, other than John Mayberry Jr.'s part-time contributions?

Pence has been the Phillies' best player this season besides Carlos Ruiz, is their only right-handed power threat, and is under control through next season. But again, that makes him more valuable to other clubs, and hence able to bring a bigger return ? probably two pieces that Amaro Jr. needs.

The Phillies have shown little interest to date in keeping Victorino out of free agency ? much as was the case with Werth. In the former, the Phils see a 33-year-old outfielder whose game is based on speed, and can envision a decline ahead. But if Pence is traded, Victorino's chances of returning increase.

Victorino is owed just over $3 million of the rest of this season, as is Joe Blanton. But as rental players heading to free agency this winter, they won't bring much in return.

The new collective bargaining agreement rules don't allow teams that acquire rent-a-players to receive draft picks when they leave through free agency. So, they're not showing the willingness to give up a highly rated prospect or valuable part for two-plus months of a rental player. For instance, the Reds reportedly turned down a Victorino-for-Logan Ondrusek proposed deal.

One way or another, Padres' third baseman Chase Headley could be a right answer, especially with Placido Polanco going on the disabled list. Headley is an above-average grinder-type (read: good fit in Philly) whose power is on the rise, and whose home/road splits suggest a nice uptick in production if he gets out of Petco Park. But he's attracting a lot of attention in this market.

So, especially in the next week leading up to the trade deadline ? and also into this off-season ? Amaro Jr. is facing his biggest challenge.

Tony DeMarco writes regularly for NBCSports.com and is a freelance writer based in Denver.


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Indians rally to beat Verlander, Tigers

CLEVELAND (AP) - Asdrubal Cabrera singled home the go-ahead run in a four-run seventh inning as the Cleveland Indians rallied to beat Detroit Tigers ace Justin Verlander 5-3 on Thursday night.

Source: http://nbcsports.msnbc.com/id/48343392/ns/sports-baseball/

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UTMB scientists awarded NIH grant for lab-grown lung tissue project

[ Back to EurekAlert! ] Public release date: 27-Jul-2012
[ | E-mail | Share Share ]

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston

New system could speed vaccine and drug testing, boost disease research

University of Texas Medical Branch at Galveston researchers have been awarded a two-year, $1.25 million National Institutes of Health grant to develop a method of custom-growing human lung tissue to make a three-dimensional model for biomedical studies.

The lab-grown piece of lung, about the size of a dime, will form the core of a system intended to provide a powerful new option for testing new vaccines and drugs and studying disease processes in the lung.

"I'm so excited that the NIH is giving us this opportunity," said UTMB professor Joan Nichols, principal investigator on the project. "We've been working on tissue engineering for a long time, and developing this kind of model has always been one of our goals. These systems could really change the paradigm of what we do."

The NIH is also funding 16 other projects aimed at developing similar models using engineered human tissues, including those for the heart, liver, kidney, intestine and skin. Ultimately, the agency hopes to connect different tissue models together, in order to create a system that could simulate the combined responses of multiple organs.

Although animal models for disease and pharmaceutical testing have a long record of success, experimental models based on engineered human tissues would offer significant advantages to researchers, Nichols said.

"First, it's a human system, and while you can simulate human responses with animal models, it's never perfect," she said. "Second, it's easily managed, and it scales up easily, because having no animal care makes everything cheaper and easier. And if the thing you're testing is toxic, it's just cells you're not killing an animal."

According to Nichols, tissue-engineered models will also give researchers the ability to more easily conduct repeated observations in live tissue and apply advanced imaging techniques such as two-photon microscopy. They should also allow researchers to study diseases for which animal models are either nonexistent or prohibitively expensive, such as hepatitis C and Ebola.

To make engineered lung tissue for the project, Nichols needs to accomplish two main tasks. First, she has to generate a "scaffold," an extracellular protein network that will give structure to her creation. Then she has to add the right cells in the right quantities to grow tissue that will act as if though it's part of a real lung.

Nichols plans to either use an artificial scaffold or harvest a natural one from a pig lung, using a process that she and co-investigator Dr. Joaquin Cortiella developed to grow mouse lungs from stem cells. Choosing what kinds of cells to grow on the scaffold, she said, will be a matter of determining the best mix to accomplish two specific objectives: generating fibrosis, an all-too-common response to drug toxicity; and testing her system's responses to different strains of influenza.

"Like any organ, the lung has a lot of different cell types in it," Nichols said. "These tissues can be as complex as we want, but it's best to just start very simple and then build off of that we can evaluate the responses of just pneumocytes, or endothelial cells and pneumocytes together, or endothelial cells and pneumocytes and immune cells, like macrophages and neutrophils. It's important to know what each individual piece does."

Nichols is confident that she'll be able to meet the goals the NIH has set for the two-year award, opening up the possibility that she'll be selected to participate in the three-year-long second phase of the project. "After this we will probably join with whoever got kidney, whoever got liver, whoever got skin and so on, as well as whoever's making the system that this will all go in," she said. "Then we'll have something really significant, with all these units linked together interacting with each other, very much like your body would normally."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 27-Jul-2012
[ | E-mail | Share Share ]

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston

New system could speed vaccine and drug testing, boost disease research

University of Texas Medical Branch at Galveston researchers have been awarded a two-year, $1.25 million National Institutes of Health grant to develop a method of custom-growing human lung tissue to make a three-dimensional model for biomedical studies.

The lab-grown piece of lung, about the size of a dime, will form the core of a system intended to provide a powerful new option for testing new vaccines and drugs and studying disease processes in the lung.

"I'm so excited that the NIH is giving us this opportunity," said UTMB professor Joan Nichols, principal investigator on the project. "We've been working on tissue engineering for a long time, and developing this kind of model has always been one of our goals. These systems could really change the paradigm of what we do."

The NIH is also funding 16 other projects aimed at developing similar models using engineered human tissues, including those for the heart, liver, kidney, intestine and skin. Ultimately, the agency hopes to connect different tissue models together, in order to create a system that could simulate the combined responses of multiple organs.

Although animal models for disease and pharmaceutical testing have a long record of success, experimental models based on engineered human tissues would offer significant advantages to researchers, Nichols said.

"First, it's a human system, and while you can simulate human responses with animal models, it's never perfect," she said. "Second, it's easily managed, and it scales up easily, because having no animal care makes everything cheaper and easier. And if the thing you're testing is toxic, it's just cells you're not killing an animal."

According to Nichols, tissue-engineered models will also give researchers the ability to more easily conduct repeated observations in live tissue and apply advanced imaging techniques such as two-photon microscopy. They should also allow researchers to study diseases for which animal models are either nonexistent or prohibitively expensive, such as hepatitis C and Ebola.

To make engineered lung tissue for the project, Nichols needs to accomplish two main tasks. First, she has to generate a "scaffold," an extracellular protein network that will give structure to her creation. Then she has to add the right cells in the right quantities to grow tissue that will act as if though it's part of a real lung.

Nichols plans to either use an artificial scaffold or harvest a natural one from a pig lung, using a process that she and co-investigator Dr. Joaquin Cortiella developed to grow mouse lungs from stem cells. Choosing what kinds of cells to grow on the scaffold, she said, will be a matter of determining the best mix to accomplish two specific objectives: generating fibrosis, an all-too-common response to drug toxicity; and testing her system's responses to different strains of influenza.

"Like any organ, the lung has a lot of different cell types in it," Nichols said. "These tissues can be as complex as we want, but it's best to just start very simple and then build off of that we can evaluate the responses of just pneumocytes, or endothelial cells and pneumocytes together, or endothelial cells and pneumocytes and immune cells, like macrophages and neutrophils. It's important to know what each individual piece does."

Nichols is confident that she'll be able to meet the goals the NIH has set for the two-year award, opening up the possibility that she'll be selected to participate in the three-year-long second phase of the project. "After this we will probably join with whoever got kidney, whoever got liver, whoever got skin and so on, as well as whoever's making the system that this will all go in," she said. "Then we'll have something really significant, with all these units linked together interacting with each other, very much like your body would normally."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-07/uotm-usa072712.php

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Amazon.com meets tiny 2Q profit expectations

SEATTLE (AP) ? Online retailer Amazon.com Inc. on Thursday reported second-quarter earnings that matched Wall Street's meager expectations, but its revenue gains and outlook for the current quarter fell short of forecasts.

Net income in the three months to June 30 came to just $7 million, or a penny per share, a drop of 96 percent from $191 million, or 41 cents, a year ago.

That matched expectations of analysts polled by FactSet, although Amazon said its profit was hurt by a $65 million loss related to its acquisition of Kiva Systems Inc., a warehouse technology company that Amazon agreed to buy in March for $775 million in cash.

Revenue grew 29 percent to $12.83 billion, short of the $12.90 billion expected by analysts.

However, Amazon said that revenue was negatively impacted by currency movements to the tune of $272 million.

After initially falling, shares rose $3.04, or 1.4 percent, to $223.05 in extended trading following the release of results.

Sales of digital goods like Kindle e-books, music and movies rose 13 percent to $4.12 billion while sales of electronics and other items rose 38 percent to $8.16 billion.

The Seattle-based company said it expects third-quarter revenue to grow between 19 percent and 31 percent from a year ago. That amounts to sales of $12.9 billion to $14.3 billion. The midpoint is short of the $14.1 billion expected by analysts.

It also forecast a third-quarter operating loss of $50 million to $350 million.

Chief Financial Officer Tom Szkutak said the projected loss was due in part to investment in the company's fulfillment centers ahead of the all-important holiday quarter.

Source: http://news.yahoo.com/amazon-com-meets-tiny-2q-profit-expectations-202055656--finance.html

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